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"Here, we developed a computational model to interrogate antibody evolution by affinity maturation after immunization with two types of immunogens: a chimeric heterotrimeric antigen that is enriched for the RBS epitope relative to other B cell epitopes, and a cocktail composed of three non-epitope-enriched homotrimeric antigens that comprise the chimera."
https://www.biorxiv.org/content/10.1101/2022.12.02.518838v1?med=mas
