"Phenotypic drug discovery has seen a general resurgence in the past 20 years, with several first-in-class drugs with no known molecular target recently approved by the US FDA, albeit largely for use outside of psychiatry [1]. We believe that phenotypic drug discovery has the potential to uncover previously unknown disease-relevant cellular signaling pathways or neural circuits and inform a deeper understanding of the pathophysiology of central nervous system diseases."

#DrugDiscovery #Neuroscience #PLOSBiology

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001904