"The amyloid cascade hypothesis was simple and “seductively compelling,” said Scott Small, the director of the Alzheimer’s Disease Research Center at Columbia University. And the idea of aiming drugs at the amyloid plaques to stop or prevent the progression of the disease took the field by storm.

Decades of work and billions of dollars went into funding clinical trials of dozens of drug compounds that targeted amyloid plaques. Yet almost none of the trials showed meaningful benefits to patients with the disease."

#Alzheimer #Amyloid #Amyloidhypothesis

https://www.quantamagazine.org/what-causes-alzheimers-scientists-are-rethinking-the-answer-20221208/