"The current model for GVHD holds that disease is maintained through the continued recruitment of alloreactive effectors from blood into affected tissues. Here, we show, using multiple approaches including parabiosis of mice with GVHD, that GVHD is instead primarily maintained locally within diseased tissues."

#Immunology #GraftVersusHost

Sacirbegovic et al @ImmunityCP https://www.cell.com/immunity/fulltext/S1074-7613(23)00013-4