Antigen independent metabolic effects of CAR constructs:

"Here we show that CARs differing only in the scFv reprogram T-cell metabolism differently. Even in the absence of antigens, some CARs increase proliferation and nutrient uptake in T cells."
#immunology #Preprint #Immunotherapy #CARTcells

https://www.biorxiv.org/content/10.1101/2023.04.03.533021v1