My latest Clinical Pipeline column for #NatureMedicine is a look at zuranolone, a new antidepressant developed by Sage & Biogen, targeting the GABA pathway.
#drugdiscovery #drugdevelopment #depression #GABA #neuroscience
@cyrilpedia Nice article. Is Zuranolone an agonist or modulator of the receptor? You use both terms in the article. It could, perhaps, be both, although the latter is more likely.
@andrewplested It's a positive allosteric regulator - sorry for the confusion (I meant agonist in the sense that it activates the channel, but in the strict sense it does not mimic the natural ligand).
