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'They observed the significant induction of IFNβ and other inducible chemokines in the medium of primary microglia treated with tau fibrils, which was abrogated by the genetic ablation of Cgas. This raised a question: how does tau protein activate this DNA sensor? Through a series of clever in vitro experiments, the authors demonstrated that tau fibrils localize to microglial lysosomes and mitochondria and that they promote the release of mitochondrial DNA (mtDNA) to the cytosol'
