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'Provision of Signal 2 from DCs to naïve T cells during priming is the second critical step [30], which usually takes the form of DC-expressed CD80 and CD86 interacting with CD28 on T cells. Consistent with this, Cd80−/−Cd86−/− mice have impaired CD8+ T cell responses after Ad5 immunization, but for reasons that remain to be elucidated Cd28−/− mice have a different phenotype: delayed but not fully impaired CD8+ T cell responses'
#Immunology #Vaccine
