"In this brief review, we present and summarize the data describing how newly described enhancers located within the large V gene portion of Igκ and Igh loci work as a higher-order mechanism for the regulation of the Ab repertoire formation by regulating chromatin interactions and epigenetic milieu, which in turn alter the 3D chromatin topology of the loci."
#immunology

https://journals.aai.org/jimmunol/article/211/11/1613/266443/Enhancers-within-the-Ig-V-Gene-Region-Orchestrate