"We show that mice lacking adaptive immune cells (rag−/− mice) do not develop clinical signs or weight loss from SARS-CoV-2 MA10 infection, whereas fully immunocompetent wild-type (WT) mice develop disease. While rag−/− mice had little to no lung pathology, virus levels were lower than WT mice early after infection, but not significantly decreased within 2 weeks of infection."
#Immunology #Virology #sarscov2
@cyrilpedia so in this model, the disease is T cell driven immunopathology?
@gpollara I doubt that in humans it would be so simple - but reinforces that the damage of immune deficiency can be outweighed by the risks of immunepathology. I think this is clearer with commensals, where you only have damage when immune dysregulation sets in. Shohei, Jocelyne & I saw this 20 years with pneumocystis:
