'In addition to illuminating previously overlooked factors relevant to intracellular macrophage pathogenesis and chronic infection, these studies highlight pronounced differences between the results of in vivo and in vitro investigatory strategies. Macrophage pathogenesis phenotypes quantitatively increased during both chronic human infection and serial passaging, and most genes implicated by in vivo and in vitro strategies were confirmed to impact macrophage pathogenesis in the same functional laboratory model. Yet, despite these phenotypic similarities, only a single candidate gene was identified in common by parallel in vivo and in vitro studies.'

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012394