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'Had we chosen something other than the C57BL/6J mouse as our primary model, the field of metabolism would look very different. A/J mice have shown us that obesity does not always go hand in hand with glucose intolerance (Bachmann et al, 2022; Karimkhanloo et al, 2023), BALB/C mice have revealed the tissue-specific nature of insulin resistance (Nelson et al, 2022), and PWK mice have demonstrated that mice do develop diet-induced NASH akin to humans (Benegiamo et al, 2023). Thus, it is to multi-strain genetic studies, the birthplace of research in mice, that we must return if we are to truly understand the pathogenesis of complex metabolic disease in humans.'
https://www.embopress.org/doi/full/10.1038/s44318-024-00221-2
@cyrilpedia "Here we make the case, as has been done by others referenced throughout this commentary, that this ‘poor translatability’ is largely due to the use of one single mouse strain in the majority of metabolic science and, for this reason, the mouse has been falsely accused. " (lol)