How do #NeuralNetworks generate diverse and variable outputs? This study of the larval #fruitfly locomotor system shows that relatively simple sets of #inhibitory circuit motifs can generate a surprising degree of diversity & variability in motor programs @PLOSBiology plos.io/3GpT3pR

Visual pathway origins: an electron microscopic volume for connectomic analysis of the human foveal retina biorxiv.org/content/10.1101/20

Visual pathway origins: an electron microscopic volume for connectomic analysis of the human foveal retina

With over 1014 synapses, the human brain presents a seemingly insurmountable challenge to a nano-scale circuit-level understanding of its diverse neural systems. The foveal retina however presents a feasible site for a complete connectome of a key human CNS structure. Foveal cells and circuits are miniaturized and compressed to densely sample the visual image at highest resolution to initiate form, color and motion perception. Here we use computational methods first applied to the fly brain to provide a draft connectome of all neurons in a foveal volume. We found synaptic connections distinct to humans linking short-wavelength sensitive cones to color vision pathways. Moreover, by reconstructing excitatory synaptic pathways arising from cone photoreceptors we found that 96% of foveal ganglion cells contribute to only three major pathways to the brain. This new resource reveals unique features of a human neural system and opens a door to its complete connectome. ### Competing Interest Statement K.L., N.K., D.I., T.N., R.L., S.P., A.H., J.A.B., J.S. and T.M. declare financial interests in Zetta AI. S.G. is owner of Aware LLC and developed the NeuroMaps.app. The remaining authors declare no competing interests.

bioRxiv

Maggots. We really don't give then enough credit. They can do so much with so little:

"Sensation of electric fields in the Drosophila melanogaster larva", Tadres et al. 2025 (Matthieu Louis' lab).
cell.com/current-biology/fullt

#neuroscience #Drosophila #ElectricSensing #DrosophilaLarva #Diptera

1 Join us for a 4-year PhD in Newcastle on a fun project (literally)!
 
Building on our recent publication about Drosophila playing on a carousel (doi.org/10.1016/j.cub.2025.01.), we will explore:
1)        the genetic underpinnings of play,
2)        the neuronal circuits involved in play, and its adaptive benefit,
3)        how environmental context impacts play behaviour.

This is what we mean when we say the regime is censuring science.

“CDC staff should not be co-authors on manuscripts/abstracts with WHO staff,” nor publish papers on work "funded by WHO.”

huffingtonpost.co.uk/entry/cdc

If we're headed into a world of minimal federal support for academic research, can I propose that we no longer view training for non-academic research as a major goal of PhD programs? 1/2

Lagged signal propagation through a dynamic graph

#openrndr #particles #graph

One of the most interesting illustrations I've seen in a while: from H. Knyazeva, S. Kurdyumov "Fundamentals of Synergetics". A stunning case of the hysteresis (history dependence) of the inference.
What are the consequences for bio- and cultural evolution?

Our story about flies on carousels is out in @CurrentBiology ! After formally engaging the fantastic Clara H. Ferreira and integrating helpful feedback from our reviewers, we now present a more concise story with detailed behavioural quantification and cooler videos: doi.org/10.1016/j.cub.2025.01.

Fascinating new research: across 26 countries, #radicalright politicians stand out as spreaders of misinformation. They are systematically poisoning the well of discourse. Hardly surprising, still somewhat shocking to see this backed up by data.
journals.sagepub.com/doi/10.11

I'm changing jobs in the next few months, and while plans are in motion, I'm curious to hear any leads folks may have. Connectomics, bioimage analysis, ML for scientific discovery. I've ~20 years of dev experience, CS BS, ML/HPC MS, neuro PhD. Mostly interested in research, staff science, or small teams/startups/founders.

Main constraint is family bound to Leipzig, so mostly looking for remote.

It is so funny to hear people in the UK talk about "creating a Silicon Valley" or "turning the UK into a hub of innovation". There are many reasons that this has not happened and will not happen, but one of the simplest reasons is that the UK cannot attract top talent when salaries in this sector are between 20% and 60% those of the US, *including* benefits such as social healthcare.

It is very interesting to think about what these people must be smoking when they say such things...

Whatsapp, like Facebook, is owned by Zuckerberg's Meta.
Signal is owned by the Signal Foundation. And it's more secure. We have a choice.

More evidence catching #publishers at gaming their journal impact factor (#JIF).
arxiv.org/abs/2501.03771

"Sneaked references are references registered in the metadata of publications without being listed in reference section or in the full text of the actual publications where they ought to be found. We document here 80,205 references sneaked in metadata of the International Journal of Innovative Science and Research Technology (#IJISRT). These sneaked references are registered with Crossref and all cite -- thus benefit -- this same journal."

#FakeCitations #Misconduct

2 Postdoc positions in experimental and computational neuroscience

George Mason University

Two postdoctoral positions in neuroscience at George Mason University (Fairfax, Virginia, USA) in the labs of Giorgio Ascoli and Holger Dannenberg

See the full job description on jobRxiv: jobrxiv.org/job/george-mason-u

#animal_behavior #behavioral_neuroscience #computational_ne...
jobrxiv.org/job/george-mason-u

The Milky Way over the Avenue of Baobabs, Madagascar.

Photo credit: Amirreza Kamkar / CC BY 4.0

We are pleased to announce the 2025 Paris Spring School in Optical Imaging and Electrophysiological Recording in Neuroscience. AKA the Paris Neuro Course.

The course will run 14-27 May 2025.

parisneuro.ovh/

Please boost (with apologies for duplicates).

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