@jackcole sure, I would never say federal supremacy is absolute, but it is a serious consideration, one that we have fortunately not had to deal with all that much historically, but it's something that's lurking there under the surface should a major federal official be sidelined from their job by a state or local government.
For what it's worth, my preference would be that we ignore this completely, and a federal official unable to do the job due to arrest would simply be seen as unable to do their job and replaced. However, I recognize the pragmatic concern and the reason this is still a factor to be considered.