the ABCs of human vaccine correlates of protection: it's
All B Cells
@Caroline_Bartma So what is the use of T cell assays (ELISpot, proliferation, etc) when assessing vaccine candidates? (I work at a CRO and we offer a range of such assays in addition to ELISA, B cell ELISpot and neutralization assays.)
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@sennoma a few ways to answer:
1. cd4 t cell help is required for good b cell responses, so t cells are definitely important, it's more that in most cases clinically, measuring antibody titers correlate with vaccine protection
2. if you are talking about animal vaccine studies, cd8 t cells can be important/required in mouse vaccine responses but maybe not as much in humans
