#SIRT6 N308K/A313S, a #Centenarian variant
⏬deacetylase/deacylase
⏫mono-ADP-ribosylase
⏬LINE1 retrotransposition
⏫DNA repair
⏫tumor killing

Lamin A is mADP-ribosylated by Sirt6!

Love to explore its benefit over blood vessels!

Dr. Andrei Seluanov, Yousin Suh, Vera Gorbunova labs EMBO J 2022
https://www.embopress.org/doi/full/10.15252/embj.2021110393