Surgery or Endovascular Therapy for #ChronicLimbThreateningIschemia
A good-quality great saphenous vein for conduit+
Surgery-first->
32%⏬risk of MALE/Death vs endovascular strategy
Dr. Alik Farber, Matthew Menard, et al BEST_CLI NEJM 2022
https://www.nejm.org/doi/10.1056/NEJMoa2207899
Our most recent #preprint (https://www.biorxiv.org/content/10.1101/2022.10.17.512253v1.full) was submitted for peer review by eLife under 'the new model' - I'm happy to share that it is now undergoing in-depth peer review. To celebrate, here's a cell that's making a little dance, guided by light
#OptoGenetics
#EndothelialCell Mst1 KO->
⏫EC inflammation by #OscillatoryShearStress 0.5±4 dyn/cm2 1 Hz
⏫🐭#Atherosclerosis
Independent of #YAP (?TAZ🧐)
Mst1 phosphorylates #Connexin43->⏬Hemichannel activity, not gap junction coupling
Dr. Ding Ai lab Circ Res 2022
https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.122.321322
RT @TonyZador@twitter.com
We used BARseq in situ sequencing to identify genes in ***1.2 million neurons*** throughout the mouse brain
We found that cortical areas with similar cell types are also interconnected. We call this “wire-by-similarity.”
https://www.biorxiv.org/content/10.1101/2022.11.06.515380v1
1/n
🐦🔗: https://twitter.com/TonyZador/status/1589804833665560577
Watch this and try not to think about the space.
Congratulations @DInoueMT 💪🏼
---
RT @DInoueMT
After reading the paper, you will get some idea to understand why two different types of chiral patterns, i.e. monopolar rotational spiral and bipolar nematic pattern, emerge from gliding microtubules.
https://twitter.com/DInoueMT/status/1589590934840573952
A few tips for newcomers, as I have learned myself in the past week...
#AltText Descriptions: Please use them, many folks here depend upon them and have been using them for years before we all arrived.
#CamelCase: when you use hashtags, use Camel Case if you have more than one word: #WelcomeToMastodon is easier to read than #welcometomastodon - so do that. Use WAAAAY more hashtags than you are used to on Twitter. Mastodon is hashtag dependent.
#ContentWarning: If you are posting something that might even in the slightest trigger another person, use the Content Warning (CW) option that you can toggle on at the bottom of the toot window. It's polite here. People can choose how they want to view and interact. Use CW more than you are used to on Twitter.
#Diversity: a few people have commented, "lots of white men here!" Well, ok, but you can also find each other by using hashtags like #WomenInStem #BlackMastodon and many more including my favorites that I started up: #Desi and #MixedDesi (i.e. me). Start your own if you don't see yourself represented, so others can find you, too.
#DMs: are under the globe option in the toot window for privacy setting and they appear in your full list / feed of notifications (don't freak out at that).
#Donations: This is all run by volunteers. Make a donation. Click on the "about this server" at the bottom of your screen (might appear in a different location than on mine) and find out who is running your server and how to make a donation. And thank them!
#Introductions: Please write a friendly intro and use the hashtag #introduction so people can learn about you. Be interested in others. Grow your community through daily, friendly interaction.
Have fun! This is like a big global cafe with many tables to sit at, and conversations to be had.
Lots more tips linked in my feed. Welcome!
Fluorescent proteins for a brighter science
https://www.sciencedirect.com/science/article/pii/S0006291X22012281
Hey everyone !
Time for my #science #introduction
I am the PI of the @cellcommlab @ the UKE in Hamburg, Germany. We use #microscopy & #imageanalysis to study how cells move & communicate.
I am from #Chile, where I did my #PhD at PUC, then moved to Paris to work at the Institut Curie and IPGG.
After quite some years in #science (20 since I started my BSc !) I keep my fascination to observe how cells do things, like these migrating leukocytes.
Arterial dictation of fetal #Hematopoiesis👹
Fetal bone marrow Bmx+ arterial #EndothelialCell (not Myh11+ mural cell) Wnt2->
⏫c-Kit+ HSPC β-catenin signals->
⏫colonization & transplant engraftment
Dr. Ralf Adams lab Nature Commmnications 2022
https://www.nature.com/articles/s41467-022-28775-x
Hi All! Happy to be here - this is my #introduction. I'm an assistant professor at the University of Amsterdam and we are creating and applying fluorescent probes for imaging of cells with microscopes.
I'm also interested in image analysis and #dataViz with #opensource tools.
#Introduction Hello, I am a postdoctoral research associate at Robarts Research Institute, Canada.
I have been studying vascular biology, with a specialized focus on Aorta & muscle microvasculature, and broad interests in biomedical & biological sciences.
Currently writing up all viable projects in my generation Hopefully to be on the job market soon.
Nice to meet everyone on Mastodon
Hi #ScienceMastodon
I’m a professor of molecular biology at UT Sorhwestern Medical Center. Our lab works on organ development, with a focus on the cardiovascular system, pancreas, kidney and lung. We use mouse models and organoids to ask questions about cell fate. Looking forward to learning and interacting here, as on Twiiter (let’s see how that site develops with the “change in leadership”).
You all are awesome for trying to explain Mastodon to me 💙 but it’s gonna take me a while 😂 (also, why can’t I attach images?) https://twitter.com/cstegman/status/1588923018868592641?s=46&t=m7OF_4G0T1KDQDYyt606gQ
#PROTAB proteolysis-targeting antibody
An evolving #PROTAC variant
Use tumor-enriched cell surface #E3Ligase RNF43/ZNRF3 for targeted degradation of transmembrane proteins IGF1R/HER2/PD-L1
Dr. N. Agard & F. de Sousa e Melo labs @Nature 2022 @genentech
https://www.nature.com/articles/s41586-022-05235-6
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op