The main difference between "man-made" machines and other simple physical #structures (#products) and #autonomous, living #systems is in the way they are "produced".
Machines are #built from the #outside by an #allopoietic process similar to #sedimentation of placing layer upon layer of "things" and connecting them to "inform" a unified single structure.
Organisms, on the other side, are single unified and integrated entities from the moment of their inception, and all their "components" #grow from the #inside out in parallel and at the same time in a closed circular #autopoietic process.