IMAGE Lab @LabPhan@qoto.org
B cells | Macrophages | Vaccines | Autoimmunity | Cancer
Joined Nov 2022
RT @JExpMed
Tingible body macrophages: Gargantuan chameleons of the germinal center. Elisa Baudon & Marc Bajenoff (https://bit.ly/3mUdBwQ) discuss recent reports from @NGurwicz, @zivshulman et al. https://bit.ly/3Y0RmCH & Grootveld et al. https://bit.ly/3ThEwyR
RT @INCITeCentre
Congratulations to Dr Tatyana Chtanova!
“We decided to use a different type of immunotherapy that targets neutrophils, to understand how generating acute inflammation in the immunosuppressive tumour microenvironment affects outcomes...”
@GarvanInstitute
https://aacrjournals.org/cancerres/article/doi/10.1158/0008-5472.CAN-21-4025/716558/Neutrophil-conversion-to-a-tumor-killing-phenotype
RT @MS_Australia
MS Australia is delighted to announce over $3 million of funding towards #MS research in 2023.
The 22 new projects address @MS_Australia’s research priorities - including causes & prevention, better treatments & cures via repair & regeneration of cells.
https://www.msaustralia.org.au/news/ms-australia-funds-over-3-million-for-ms-research-grants-in-2023/
RT @LaskerFDN
that #macrophages residing in the follicle during resting state can mature into TBMs in the presence of apoptotic cells, even in the absence of germinal centers. http://ow.ly/PRHa50Nez27
RT @LaskerFDN
Tingible body macrophages (TBMs) clear cellular debris from germinal centers upon infection and vaccination, helping to prevent the spread of self antigens. It is unclear if TBM-like cells are present in the resting lymph node. Now, scientists find
We are hiring! @INCITeCentre is growing and we are looking for talent to join our team to look into the dark space of tumours. Please DM for more info. Please RT 🙏
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RT @INCITeCentre
🚨 JOB ALERT🚨 Interested in working on #tumor #metastasis, #cancer cell #dormancy, #autoimmunity and using high resolution #imaging? Apply to us! #recruiting #intravital #INCITe
@LabPhan @Timpson_Lab @GarvanInstitute
DM if interested!
https://www.natu…
https://twitter.com/INCITeCentre/status/1632876999151865861
That’s a great question!
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RT @King_Lab_McGill
Incredibly beautiful work on tingible body macrophages, a mysterious and difficult population to study. So how do they interact with FDCs and Tfh cells?? https://www.cell.com/cell/fulltext/S0092-8674(23)00106-X?dgcid=raven_jbs_aip_email#%20
https://twitter.com/King_Lab_McGill/status/1631630767808823300
RT @CellCellPress
Now online! Apoptotic cell fragments locally activate tingible body macrophages in the germinal center http://dlvr.it/SkGV0J
RT @GarvanInstitute
Garvan researchers have made a fundamental discovery about the workings of a key type of garbage disposal cell that plays a role in autoimmune disorders.
Read more: http://ow.ly/KsyL50N7Tv0
Amazing work Abi! You can prove me wrong anytime!
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RT @AbigailGroot129
Excited to share my PhD research investigating the origin and dynamics of germinal centre tingible body macrophages. Online @CellCellPress
Great working with co-first @wunniess @GarvanInstitute @LabPhan & our collaborators Veera Panova & Oliver Bannard https://tinyurl.com/5n86w92f
https://twitter.com/AbigailGroot129/status/1631467076266377216
RT @Lo_Zanzi
#LocationLocationLocation! @LabPhan @AbigailGroot129 @wunniess show @CellCellPress dying #GerminalCenter B cells activate tingible body macrophages that “use cytoplasmic processes to chase and capture migrating dead cell fragments” preventing #autoimmunity https://doi.org/10.1016/j.cell.2023.02.004
RT @profcelentyx
#Bcells are Dying to Activate #TingibleBodyMacrophages | Fundamental New Insights into #GerminalCentre Biology Militating against #AutoImmuneDisease | Great Work by @AbigailGroot129 @wunniess @LabPhan @GarvanInstitute @UNSWMedicine at @CellCellPress 👏 | https://www.cell.com/cell/fulltext/S0092-8674(23)00106-X
4/ We used CD169 lineage reporter to track TBM origin & cellular dynamics by intravital microscopy @INCITeCentre. The idea for CD169 came from work in Cyster lab @UCSF back in 2007. We had noted some CD169+ SSM migrated into follicle after immunization.
3/ But "tingible" bodies are in fact corpses of dead & dying B cells from GC selection. Removing the potentially self-reactive nuclear & cytoplasmic debris from these cells is critical housekeeping function to prevent autoimmune diseases like SLE. How does this work?
2/ Tingible body macrophages (TBMs) are as old as the GC! First described Fleming 1885 and possibly thought to contain lymphocytes about to be born! Hence "germinal" centre. Also described by pathologists in Hodgkin's as giving "starry sky" appearance to GC as per Van Gogh.
1/ So proud of PhDs @AbigailGroot129 & @wunniess @GarvanInstitute @UNSWMedicine their first paper now out @CellCellPress. Amazing collab with Veera Panova & Oliver Bannard @UniofOxford, David Hume @UQMedicine, @tanmay_mitra_ @Helmholtz_HZI & many more.
RT @LabWaggoner
Non-migratory tingibile body macrophages are pre-positioned in the follicle and use cellular processes to capture and remover motile dead cell fragments from the germinal center @CellCellPress @LabPhan
@GarvanInstitute @AbigailGroot129
https://www.cell.com/cell/fulltext/S0092-8674(23)00106-X
Thx Dany! It’s been a great journey good to have you cheering us on!
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RT @dany_butt
Seminal work from Tri Phan @LabPhan and colleagues! Shedding light on the origins of Tingible Body Macrophages in the GC and function. Kudos to the whole team! https://www.cell.com/cell/fulltext/S0092-8674(23)00106-X
https://twitter.com/dany_butt/status/1631352759055179778
RT @ReboldiLab
Check out our #immunometabolism study on how Tgd17 cells are educated in the thymus to sense oxysterol through GPR183 and home to the skin towards depots of GPR183 ligand. A fantastic collaboration between our lab and Joonsoo Kang’s lab. #gammadeltaTcells #keratinocytes https://twitter.com/frascolimichela/status/1629518406759202817
B cells | Macrophages | Vaccines | Autoimmunity | Cancer
Joined Nov 2022
