IMAGE Lab @LabPhan@qoto.org
B cells | Macrophages | Vaccines | Autoimmunity | Cancer
Joined Nov 2022
RT @CIRCA_genomics
New work by CIRCA members @ElissaDeenick and @DeenickLab , @stutangye and @Tangye_Lab @GarvanInstitute Unravelling complexities of human disease due to germline variants in PIK3D and PIK3R1 causing #APDS. @AllaboutAPDS https://twitter.com/jexpmed/status/1640721174949658624
Thank you Mohamed for another concise and precise thread that really captures the state-of-the-art!
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RT @Plasmacellguy
(1) The plasma cell (PC) field has been booming and blooming in the past two years
Some dogmas and notions were quietly taken apart
An #immunology 🧵
https://twitter.com/Plasmacellguy/status/1640903473926402049
Good to see @ChrisMinnsMP & @NSWHealth at work! Looking forward to seeing implementation of @ascia_news national immunodeficiency strategy & proud to support @AYKane work towards better model of care for neglected patients with rare primary immunodeficiency diseases.
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RT @AYKane
Great to meet @ChrisMinnsMP at Liverpool hospital today. Hope to work with you to improve access to treatments for rare primary immune deficiencies https://www.n…
https://twitter.com/AYKane/status/1640664547525812224
RT @m_steain
Do you like your covid-19 vaccines to give you a good dose of neutralising antibodies? You should because we've shown they correlate not only with protection from symptomatic but also severe disease! Another great collab with @DebCro https://www.nature.com/articles/s41467-023-37176-7
This is great news for myeloma patients! Well done getting this platform trial off and running @gjmccaughan & @HangQuach1 & @ALLGtrials !
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RT @gjmccaughan
Has been fantastic developing this trial with @HangQuach1 and @ALLGtrials to explore novel agents in patients with multiple myeloma who are typically excluded from clinical trials - looking forward to opening sites across Australia and the Asian Myeloma Network soon! https://twi…
https://twitter.com/gjmccaughan/status/1638815018539175937
Congrats Yuki et al! Great summary of arcane field! Mast cells link Staph aureus skin colonisation and eczema. Maybe also explains paradox of why boils and eczema in AD-HIES with STAT3 DN have less food allergy and anaphylaxis?
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RT @_Claudiadotcom
Happy to share our new review on “Mast cells in type 2 skin inflammation”@EurJImmunol ! How are mast cells maintained and what do they do in atopic dermatitis? https://onlinelibrary.wil…
https://twitter.com/_Claudiadotcom/status/1638510938654646272
RT @khanna_rajiv
Check our review "Adoptive T-cell therapy targeting Epstein–Barr virus as a treatment for multiple sclerosis" published in @ClinTransImmuno http://bit.ly/3Z88ypY
@QIMRBerghofer @msresearch @Atarabio @MS_Australia @msqld @mssocietysant @MSNewsToday @MSViewsandNews
So much to like in this paper dissecting molecular pathogenesis of APDS1 & APDS2. Human <=> mouse. Curious how these rare monogenic PIDs will inform common polygenic autoimmune diseases like SLE. Dysregulation of PI3K pathway may not be so rare!
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RT @ElissaDeenick
Out today in @JExpMed our @DeenickLab paper comparing APDS1 and APDS2. We show while these two conditions are similar, not all PI3K dysregulation is the same. Great coll…
https://twitter.com/ElissaDeenick/status/1638361339189170177
So happy to see this out @JExpMed - epic effort led by @ElissaDeenick #Scientia A/Prof @UNSWMedicine & @GarvanInstitute. PIK3R1 LOF & PIKCD GOF - same but diff't! Amazing collab with @Tangye_Lab et al. Big congrats to 1st authors Nguyen, Lau & @bier_julia!
https://rupress.org/jem/article/220/6/e20221020/213955/Human-PIK3R1-mutations-disrupt-lymphocyte
RT @JExpMed
Detailed analysis of patients with APDS2 & a novel mouse model of Pik3r1 LOF reveals multiple cellular defects, some of which are unique to APDS2 & not seen in APDS1. From Nguyen, Lau, Bier, @stutangye @ElissaDeenick et al @GarvanInstitute: https://bit.ly/42rfmlB
@Abolhassanih
RT @Grace_Mcauley
Today we report in @CellCellPress, a study led by the labs of Donald Kohn (@kohnlab) and Gay Crooks in collaboration with @davidrliu's team, in which we utilized adenine base editing to correct the mutation that causes CD3 delta severe combined immunodeficiency in HSPCs (1/8) https://t.co/3eW46t4sOJ
RT @JGrutzendler
TREM2 and APOE do not modulate phagocytic clearance of dying cells!
Live imaging of cell death and phagocytosis in Alzheimer's mice.
From @eyiyemisi @bobalhill, Anu Rai from @JGrutzendler lab @NeurologyYale @WuTsaiYale @YaleNeuro @dartmouth #Alzheimers
https://www.biorxiv.org/content/10.1101/2023.03.17.533222v1
RT @vinodscaria
▶️ Clinical application of polygenic risk scores (PRS) - @TheACMG statement
Does not provide Diagnosis
Does not rule out significant risk
Poor transferability across Populations
Limited evidence to support clinical management
https://www.gimjournal.org/article/S1098-3600(23)00816-X/fulltext
RT @Caroline_Bartma
Now that we have a human cell atlas can we have a human cell googlemaps
“I just passed a macrophage and two fibroblasts, WHERE AM I?”
RT @zivshulman
New publication alert 💥. Liat Stoler-Barak, a talented lab staff scientist 🥇, found that class switch recombination (CSR) depends on Dyrk1a, a kinase associated with Down syndrome. https://www.nature.com/articles/s41467-023-37205-5. @GurYaari @iannaconelab @WeizmannScience
RT @AlexanderDent6
“TBMs use cellular processes to search for and capture motile apoptotic cell fragments”. I have a funny image of a piece of a cell breaking off & still being able to move like a chicken running around with its head cut off. Very cool study though! https://www.cell.com/cell/fulltext/S0092-8674(23)00106-X?dgcid=raven_jbs_etoc_email
Link to tweetorial on @zivshulman paper:
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RT @zivshulman
During antibody affinity maturation in germinal centers (GCs), many defective B cells die by apoptosis. These cells are removed by tingible body macrophages (TBMs). Here, we describe their origin and function. 🧵@NGurwicz https://doi.org/10.1084/jem.20222173 @JExpMed
https://twitter.com/ZivShulman/status/1619003990242635776
Link to tweetorial on our paper:
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RT @LabPhan
1/ So proud of PhDs @AbigailGroot129 & @wunniess @GarvanInstitute @UNSWMedicine their first paper now out @CellCellPress. Amazing collab with Veera Panova & Oliver Bannard @UniofOxford, David Hume @UQMedicine, @tanmay_mitra_ @Helmholtz_HZI & many more.
https://www.cell.com/cell/fulltext/S0092-8674(23)00106-X
https://twitter.com/LabPhan/status/1631392015643729920
Many thanks to Laudon & @BajenoffL for their insightful commentary @JExpMed on @NGurwicz @zivshulman @WeizmannScience and @AbigailGroot129 @wunniess @GarvanInstitute in @CellCellPress on TBMs - the gargantuan chameleon of the germinal centre!
RT @zivshulman
A fantastic summary and interpretations of our (@NGurwicz) and Grootveld @LabPhan et al findings about Tingible body macrophages in germinal centers. Thanks to Elisa Baudon and Marc Bajenoff! @JExpMed @CellCellPress https://twitter.com/jexpmed/status/1635716197286301696
B cells | Macrophages | Vaccines | Autoimmunity | Cancer
Joined Nov 2022
