IMAGE Lab @LabPhan@qoto.org
B cells | Macrophages | Vaccines | Autoimmunity | Cancer
Joined Nov 2022
RT @GarvanInstitute
April 29 is International Day of Immunology, a day to highlight the broad and deep impact that immunology has on our society. Hear why Dr Katherine Jackson is so passionate about being an immunologist. #DayofImmunology
RT @ShahFA_
🚨Dancing Osteocytes!💃🏻🕺🏻~90–95% of all cells in adult bone are #osteocytes interconnected by a vast network of #canaliculi. They play a key role in maintaining #bone health by sensing mechanical loading and orchestrating remodelling! 🦴🔎🔬
Read more: http://bit.ly/OsteocyteRCE
Fantastic work from @max_nobis_ @Timpson_Lab et al @INCITeCentre @GarvanInstitute. State-of-the-art intravital imaging thanks to @Cancer_Research. You can read the paper @ScienceAdvances.
https://www.science.org/doi/10.1126/sciadv.adf9063
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RT @9NewsSyd
Sydney researchers are using sophisticated imaging to analyse cancer cells in "real-time” to pinpoint why some resist treatment.
Their work is vital in the mission to combat one of Aus…
https://twitter.com/9NewsSyd/status/1651869031341883392
Wow!
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RT @coledeforest
PUMPED that our paper introducing Light-Activated SpyLigation (#LASL) is now live at @NatureChemistry! We show bioactive proteins can be stably photo-assembled from split fragment pairs in solution, in biomaterials, and in living mammalian cells.
https://www.nature.com/articles/s41557-023-01152-x
(1/13)
https://twitter.com/coledeforest/status/1647982063323328512
Ouchterlony double immuno diffusion! 😍
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RT @Montse_JExpMed
In honor of the 30th annual Henry Kunkel Society Meeting on Protective and Pathogenic #Plasma Cells, here is a #JEMLegacy from Henry Kunkel himself on human #MultipleMyeloma proteins and antibodies. https://doi.org/10.1084/jem.101.1.85 Hope to see you around campus!
https://twitter.com/Montse_JExpMed/status/1646570443657338886
RT @zhangf
Delivery of therapeutic molecules is a major bottleneck for treating a wide range of diseases. Today we describe a new modality for delivering proteins based on an engineered contractile injection system @Nature https://www.nature.com/articles/s41586-023-05870-7
Good to see @ChrisMinnsMP & @NSWHealth at work! Looking forward to seeing implementation of @ascia_news national immunodeficiency strategy & proud to support @AYKane work towards better model of care for neglected patients with rare primary immunodeficiency diseases.
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RT @AYKane
Great to meet @ChrisMinnsMP at Liverpool hospital today. Hope to work with you to improve access to treatments for rare primary immune deficiencies https://www.n…
https://twitter.com/AYKane/status/1640664547525812224
RT @JExpMed
Detailed analysis of patients with APDS2 & a novel mouse model of Pik3r1 LOF reveals multiple cellular defects, some of which are unique to APDS2 & not seen in APDS1. From Nguyen, Lau, Bier, @stutangye @ElissaDeenick et al @GarvanInstitute: https://bit.ly/42rfmlB
@Abolhassanih
RT @JGrutzendler
TREM2 and APOE do not modulate phagocytic clearance of dying cells!
Live imaging of cell death and phagocytosis in Alzheimer's mice.
From @eyiyemisi @bobalhill, Anu Rai from @JGrutzendler lab @NeurologyYale @WuTsaiYale @YaleNeuro @dartmouth #Alzheimers
https://www.biorxiv.org/content/10.1101/2023.03.17.533222v1
Link to tweetorial on @zivshulman paper:
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RT @zivshulman
During antibody affinity maturation in germinal centers (GCs), many defective B cells die by apoptosis. These cells are removed by tingible body macrophages (TBMs). Here, we describe their origin and function. 🧵@NGurwicz https://doi.org/10.1084/jem.20222173 @JExpMed
https://twitter.com/ZivShulman/status/1619003990242635776
RT @JExpMed
Tingible body macrophages: Gargantuan chameleons of the germinal center. Elisa Baudon & Marc Bajenoff (https://bit.ly/3mUdBwQ) discuss recent reports from @NGurwicz, @zivshulman et al. https://bit.ly/3Y0RmCH & Grootveld et al. https://bit.ly/3ThEwyR
RT @GarvanInstitute
Garvan researchers have made a fundamental discovery about the workings of a key type of garbage disposal cell that plays a role in autoimmune disorders.
Read more: http://ow.ly/KsyL50N7Tv0
3/ But "tingible" bodies are in fact corpses of dead & dying B cells from GC selection. Removing the potentially self-reactive nuclear & cytoplasmic debris from these cells is critical housekeeping function to prevent autoimmune diseases like SLE. How does this work?
2/ Tingible body macrophages (TBMs) are as old as the GC! First described Fleming 1885 and possibly thought to contain lymphocytes about to be born! Hence "germinal" centre. Also described by pathologists in Hodgkin's as giving "starry sky" appearance to GC as per Van Gogh.
RT @QuantaMagazine
This “living crystal” is a clump of rotating, jiggling starfish embryos in the lab of the biophysicist Nikta Fakhri. It embodies a state of matter known as an odd material that may have previously unknown biological functions. https://www.quantamagazine.org/starfish-whisperer-develops-a-physical-language-of-life-20230111/
Great Google map view from up high of where we are and how to get to where we want to be to solve MS. Looking forward to the whole Special Feature in @ClinTransImmuno !
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RT @khanna_rajiv
Fantastic Special Feature review on "Mechanisms for EBV triggering of MS" https://bit.ly/3SaONw8 by @TobiasLanz, William Robinson and Larry Steinman from @StanfordMed, @Stanford and @StanfordRheum @msresearch @MS_Australia @MS_HealthUnion @MStransl…
https://twitter.com/khanna_rajiv/status/1627461639934205952
RT @erturklab
Imagine you could stain whole adult mice with standard IgG antibodies. What you couldn't do! We present wildDISCO technology for this🤗, creating the first whole body vascular, lymphatic, and nerve atlases. By @HongchengM @jieluo692 https://www.biorxiv.org/content/10.1101/2023.02.17.528921v1.full.pdf 🧵👇🏼(turn on the sound)
RT @CiminiLab
New exciting preprint about microscopes and Cell Painting ⚠️ Pop into 🧵and learn more about "Assessing the performance of the Cell Painting assay across different imaging systems" from @nasim_jamali and Callum Tromans-Coia et al 1/x https://www.biorxiv.org/content/10.1101/2023.02.15.528711v1
B cells | Macrophages | Vaccines | Autoimmunity | Cancer
Joined Nov 2022
