Marom Bikson @MaromBikson@qoto.org
Biomedical engineer and scientist. Interested in medical devices that translate scientific innovation to patients - design, testing, regulatory, deployment...
"Neuro-vascular modulation: What a new mechanism suggests about how brain stimulation works and how to interpret hemodynamic imaging?" at the 3rd Annual Brain & Human Body Modeling (BHBM) Conference, Aug 18, 2024.
https://youtu.be/Sg7AN4SGx74?si=tKSJAT7GceewNtP1
Announcing Neuromodec Webinar Series!
Running a free webinar series, presenting the latest and more innovative updates in brain recording and modulation. Each webinar will be independently hosted by leaders in the field. Learn more 👉 https://neuromodec.org/webinar-series-2024/
New publication: 2023 update onLOTES standard for Limited-Output Transcranial Electrical Stimulation device design.
-International regulatory standards consolidation (with EU aberration).
-Updated label precautions including for pediatrics & in pregnancy.
https://www.sciencedirect.com/science/article/pii/S1935861X23017758
New publication: "Novel Evoked Synaptic Activity Potentials (ESAPs) elicited by Spinal Cord Stimulation."
In a rodent Spinal Cord Stimulation (SCS) model we report that in addition to fast Evoked Compound Action Potentials (ECAPs) there are later slower signals we call: Evoked Synaptic Activity Potentials (ESAPs).
Why does this matter for Spinal Cord Stimulation (SCS) therapy:
1) ECAPs reflect only conduction of dorsal column axons, not necessarily a spinal circuit response. But ESAPs reflect network/synaptic activity within the dorsal horn. (We definitively show ESAPs are not myogenic). ESAPs may be a unique maker of pain / SCS state.
2) Slow potentials in human spinal electrophysiology have been studied for decades. Our study bridges this vast literature into modern SCS but showing slow signals from the dorsal horn can be evoked/detected with percutaneous SCS leads (i.e. existing SCS hardware).
3) But we show ESAPs require more nuance (than ECAPs) to detect. We suggest this is a *virtue* in providing insights for SCS optimization and mechanisms. It's no coincidence the originators of the pain gate-control-theory (Wall & Melzack) studied slow spinal potentials!
https://www.eneuro.org/content/10/5/ENEURO.0429-22.2023.long
Neuromodulation for COVID-19, Neuromodec update 8: Encouraging news
This is the 8th update from Neuromodec on the use of #Neuromodulation for #COVIDー19 as part of Neuromodec’s initiative to educate on and advance treatments.
https://neuromodec.org/2023/02/neuromodulation-for-covid-update-ecouraging-news/
New publication:
"Quasi-static pipeline in electroconvulsive therapy computational modeling".
How are 'static' & 'dynamic' impedance determined in ECT?
Can ECT models use a quasi-static assumption if impedance is complex?
https://www.brainstimjrnl.com/article/S1935-861X(23)01707-2/fulltext
New Book Chapter: "Noninvasive Electrical Brain Stimulation of the Central Nervous System" in Handbook of Neuroengineering
https://static1.squarespace.com/static/5cd3231cd7819e6ae55fedb4/t/623731b9fd31932c6ff5cc33/1647784379168/Khadka-Bikson2022_NoninvasiveElectricalBrainStim.pdf
In this talk (part 4 of it) I explain how "functional targeting" supports boosting of ongoing plasticity by tDCS. And how 'functional targeting' modulates ongoing oscillations. All part of a conceptual framework of "tDCS of cortical columns". https://www.youtube.com/watch?v=vBO_1AwcWqg
More recent work enhances these ideas including @lcparra showing 'functional targeting' down to the synapse level as "tDCS boosts Hebb". https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989352/
Important to reserve judgment about #Neuralink anima welfare questions until facts are clear. But I wrote about "While Silicon Valley can afford to hire top expertise...it is unclear how fast certain medical R&D processes can be accelerated through (or around) these regulations & standards." https://neuromodec.org/2021/11/what-silicon-valley-needs-to-know-about-the-brain-and-what-it-doesnt/
Can machine learning predict risk of developing breast cancer in the future from the current mammogram? Can we use that to personalize screening?
Join us this Thursday Dec 1st at 11AM (ET) online for a conversation with Adam Yala from UC Berkeley https://pubmed.ncbi.nlm.nih.gov/34767469/
Coordinates for the event and other conversations : https://sites.google.com/view/ai-breast-mri/
You can check out news about by lab here: https://www.neuralengr.org/
Especially given Neuralinks recent "demo" here is my essay on "What Silicon Valley needs to know about the brain, and what it doesn't". https://neuromodec.org/2021/11/what-silicon-valley-needs-to-know-about-the-brain-and-what-it-doesnt/
Neuromodec is a good website for listing up upcoming events in neuromodulation and neuro-technology, job postings, and more. All free. https://neuromodec.org/
My lecture at the Medical University of South Caroline (MUSC) on "Transcranial electrical stimulation (tES) technology: A difference to be a difference must make a difference."
I focus on what makes computational models of current flow useful in the development of better neuromodulation, especially transcranial Direct Current Stimulation (tDCS)
Video record: https://player.vimeo.com/video/725708482?h=6a59597395
Hello. My name is Marom Bikson. I am a biomedical engineer in developing devices to treat brain disorders. You can find all my papers here: https://www.neuralengr.org/bikson
Biomedical engineer and scientist. Interested in medical devices that translate scientific innovation to patients - design, testing, regulatory, deployment...
