Phil Rivera boosted
Aging Highlights

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease

#alzheimer #neuroscience

nature.com/articles/s41593-023

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Phil Rivera boosted
jobRxiv

Multiple US faculty positions currently open in different fields #Bioinformatics #Genomics #Immunology #Biotech #Aging #ComputerScience #Engineering #neuroscience
🧵

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Phil Rivera boosted
Danai Riga

For the #astrocyte lovers out there: fantastic new work from Aina Badia et al., showing ezrin-mediated PAP retraction in fear learning!
Such.Pretty.Data ❤️😍🌟

Retraction of Astrocyte Leaflets From the Synapse Enhances Fear Memory - Biological Psychiatry
biologicalpsychiatryjournal.co

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Phil Rivera boosted
Medical Xpress (Unofficial)

A drug that increases dopamine can reverse the effects of inflammation on the brain in depression

An Emory University study published in Molecular Psychiatry shows levodopa, a drug that increases dopamine in the brain, has potential to reverse the effects of inflammation on brain reward circuitry, ultimately improving symptoms of depression.

medicalxpress.com/news/2023-01

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Phil Rivera boosted
Jaan Aru

Finally, we figured out the new identity and the lab logo. I hope we nailed it …👇

And here’s a new paper to illustrate our work: we compare Theory of Mind processes in natural and artificial intelligence.

Out now in Artificial Intelligence Review: link.springer.com/article/10.1

arxiv version: arxiv.org/pdf/2203.16540.pdf

#AI #lab #introduction

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Phil Rivera boosted
bioRxiv

Behavioral pattern separation and cognitive flexibility are enhanced in a mouse model of increased lateral entorhinal cortex-dentate gyrus circuit activity biorxiv.org/content/10.1101/20

Behavioral pattern separation and cognitive flexibility are enhanced in a mouse model of increased lateral entorhinal cortex-dentate gyrus circuit activity

Behavioral pattern separation and cognitive flexibility are essential cognitive abilities which are disrupted in many brain disorders. Better understanding of the neural circuitry involved in these abilities will open paths to treatment. In humans and mice, discrimination and adaptation rely on integrity of the hippocampal dentate gyrus (DG) which both receive glutamatergic input from the entorhinal cortex (EC), including the lateral EC (LEC). Inducible increase of EC-DG circuit activity improves simple hippocampal-dependent associative learning and increases DG neurogenesis. Here we asked if the activity of LEC fan cells that directly project to the DG (LEC→DG neurons) regulates behavioral pattern separation or cognitive flexibility. C57BL6/J male mice received bilateral LEC infusions of a virus expressing shRNA TRIP8b, an auxiliary protein of an HCN channel or a control virus (SCR shRNA); this approach increases the activity of LEC→DG neurons. Four weeks later, mice underwent testing for behavioral pattern separation and reversal learning (touchscreen-based Location Discrimination Reversal [LDR] task) and innate fear of open spaces (elevated plus maze [EPM]) followed by counting of new DG neurons (doublecortin-immunoreactive cells [DCX+] cells). TRIP8b and SCR shRNA mice performed similarly in general touchscreen training and LDR training. However, in late LDR testing, TRIP8b shRNA mice reached the first reversal more quickly and had more accurate discrimination vs. SCR shRNA mice, specifically when pattern separation was challenging (lit squares close together or small separation). Also, TRIP8b shRNA mice achieved more reversals in late LDR testing vs. SCR shRNA mice. Supporting a specific influence on cognitive behavior, SCR shRNA and TRIP8b shRNA mice did not differ in total distance traveled or in time spent in the closed arms of the EPM. Supporting an inducible increase in LEC-DG activity, DG neurogenesis was increased. These data indicate TRIP8b shRNA mice had better pattern separation and reversal learning and more neurogenesis vs. SCR shRNA mice. This work advances fundamental and translational neuroscience knowledge relevant to two cognitive functions critical for adaptation and survival —behavioral pattern separation and cognitive flexibility — and suggests the activity of LEC→DG neurons merits exploration as a therapeutic target to normalize dysfunctional DG behavioral output. ### Competing Interest Statement The authors have declared no competing interest.

www.biorxiv.org
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Phil Rivera boosted
Medical Xpress (Unofficial)

Gum infection may be a risk factor for heart arrhythmia, researchers find

Periodontitis, a gum disease, can lead to a litany of dental issues from bad breath to bleeding and lost teeth. Now, researchers at Hiroshima University have found that it could be connected to even more severe problems elsewhere in the body—the heart.

medicalxpress.com/news/2023-01

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Phil Rivera boosted
Luigi Petrucco

Introduction! I am a biologist and neuroscientist. I got a PhD in systems #neuroscience in the Portugues lab imaging the brain of #zebrafish larvae, where described a mesmerising circuit for heading direction in the hindbrain (doi.org/10.1101/2022.04.27.489).

I recently moved to the lab of Giuliano Iurilli at IIT (Rovereto, Italy) to follow up in mice my interest in subcortical circuits for naturalistic behavior.

I'm a fan of #openscience, #Python, and unconventional paradigms. Cortex is overrated!

GIF
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Phil Rivera boosted
bioRxiv

A comparative analysis of microglial inducible Cre lines biorxiv.org/content/10.1101/20

A comparative analysis of microglial inducible Cre lines

Cre/LoxP technology has revolutionized genetic studies and allowed for spatial and temporal control of gene expression in specific cell types. The field of microglial biology has particularly benefited from this technology as microglia have historically been difficult to transduce with virus or electroporation methods for gene delivery. Here, we interrogate four of the most widely available microglial inducible Cre lines. We demonstrate varying degrees of recombination efficiency and spontaneous recombination, depending on the Cre line and loxP distance. We also establish best practice guidelines and protocols to measure recombination efficiency in microglia, which could be extended to other cell types. There is increasing evidence that microglia are key regulators of neural circuit structure and function. Microglia are also major drivers of a broad range of neurological diseases. Thus, reliable manipulation of their function in vivo is of utmost importance. Identifying caveats and benefits of all tools and implementing the most rigorous protocols are crucial to the growth of the field of microglial biology and the development of microglia-based therapeutics. ### Competing Interest Statement The authors have declared no competing interest.

www.biorxiv.org
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Phil Rivera boosted
Medical Xpress (Unofficial)

Children near airports may be exposed to dangerous levels of lead

A new paper in PNAS Nexus finds that children living near one California airport have higher lead levels in their blood. Since leaded gasoline is still used by piston-engine aircraft all around the United States, it appears children are still being exposed to toxic lead levels. This is despite policymakers' efforts to reduce lead exposure since the 1970s.

medicalxpress.com/news/2023-01

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Phil Rivera boosted
Yael Niv

Senior faculty are incredibly powerful. In a two-page tenure letter, they can make or break a career. This power has an outsized impact on scholars with marginalized identities, such as Black academics, who are promoted with tenure at lower rates than their white colleagues.

Are you a senior faculty? Do you want to align your letters with your anti-racist values? A group of us, educated at #A4BL to disrupt anti-Black racism in academia, suggest practical steps how:

elifesciences.org/articles/798

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Phil Rivera boosted
Tristan Manfred Stöber

RT @ikebukuro_tomu
Happy to announce that as of 1/1 I am the new Editor-in-Chief of Neuroscience Research (sciencedirect.com/journal/neur) the official journal of the Japan Neuroscience Society. We strive for quick, rigorous and fair decisions, so please consider submitting across all fields

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Phil Rivera boosted
Rebecca Hirst

All the questions today!

Can anyone recommend any papers on large-scale international studies on differences in perceptual effects? e.g. illusions

🌏 🌍 🌎

#psychophysics #vision #auditory #perception #research #psychology #neuroscience

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Phil Rivera boosted
Earl K. Miller

Silent synapses are abundant in the adult brain
These immature connections may explain how the adult brain is able to form new memories and absorb new information.
news.mit.edu/2022/silent-synap

#neuroscience

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Phil Rivera boosted
Danai Riga

Is it too early to get excited about this?

#stress #neuroscience #conference

4th EWCS | Max Planck Institute of Psychiatry
psych.mpg.de/4th-ewcs

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Phil Rivera boosted
francoisguite

Study: Network neuroscience theory best predictor of intelligence | University of Illinois news.illinois.edu/view/6367/93

Investigating cognitive neuroscience theories of human intelligence: A connectome-based predictive modeling approach | Human Brain Mapping onlinelibrary.wiley.com/doi/10
#OpenAccess #neuroscience

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Phil Rivera boosted
Earl K. Miller

Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia
nature.com/articles/s41386-021

#neuroscience

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Phil Rivera boosted
Janet Iwasa

Beautiful illustration from postdoc Margot Riggi (@MargotRiggi on Twitter) depicting a cross-section of Asgard archaea with actin filaments within. Based on recently published work from the Pilhofer Lab: nature.com/articles/s41586-022

Illustration of Asgard archaea in cross section, showing actin filaments and ribosomes within.
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Phil Rivera boosted
Rebecca Hirst

Spotted on that bird platform (shared by Prof Lauren Ball) and resharing for matadonians!

"Writing a scientific article: A step-by-step guide for beginners"

#researchskills #writingtips #scicomm

sciencedirect.com/science/arti

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Phil Rivera boosted
Fanny Cazettes

Do you want to learn about systems neuroscience?

We have an open position to work as a research assistant in sunny Marseille: emploi.cnrs.fr/Offres/CDD/UMR7

Please, help spread the word!

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