1/ PyVBMC 1.0 is out! 🎉

github.com/acerbilab/pyvbmc

A new Python package for efficient Bayesian inference.

Get a posterior distribution over model parameters + the model evidence with a small number of likelihood evaluations.

No AGI was created in the process!

RT @doellerlab
"Entorhinal grid-like codes and time-locked network dynamics track others navigating through space"

Interesting work in @NatureComms by @isabellawagnr, @LuisePhil, @boryana_td, Andre Lüttig, @DavidOmer_, @MatStangl & @ClausLamm

nature.com/articles/s41467-023

RT @Vincent_T_D
Super thrilled that this piece is now out in @PNASNexus! In the paper, we discuss whether a GAN-like process could explain intrusive imagery experiences in disorders such as PTSD. Congrats @CA_Cushing @alexeijoel @SHofmann1512 @hakwanlau @theamygdaloid academic.oup.com/pnasnexus/adv

This is *not* the way scientific papers typically begin:
_________________________

We are running out of time. Ecosystems across the planet are being destroyed at an accelerating rate. The life sciences – once a field dedicated to the study of living systems and our interactions with them – are increasingly becoming sciences of the dead. Up to one million species are currently threatened with extinction, many of them within decades.
_________________________

It's a very good sign, however, an indication that at least some scientists are now ready to speak boldly and unequivocally about the greatest emergency our species has ever faced.

SEE THE FULL PAPER -- elifesciences.org/articles/832

#ClimateEmergency #BiodiversityLoss #Extinction

RT @PMuhleKarbe@twitter.com

Excited to share our latest work, examining how navigational goals distort the representation of space:
Great team effort with @hannahsheahan@twitter.com @GiovanniPezzulo@twitter.com @hugospiers@twitter.com #SamsonChien @nico_schuck@twitter.com @summerfieldlab@twitter.com
biorxiv.org/content/10.1101/20

🐦🔗: twitter.com/PMuhleKarbe/status

Goal-seeking compresses neural codes for space in the human hippocampus and orbitofrontal cortex

Humans can navigate flexibly to meet their goals. Here, we asked how the neural representation of allocentric space is distorted by goal-directed behaviour. Participants navigated an agent to two successive goal locations in a grid world environment comprising four interlinked rooms, with a contextual cue indicating the conditional dependence of one goal location on another. Examining the neural geometry by which room and context were encoded in fMRI signals, we found that map-like representations of the environment emerged in both hippocampus and neocortex. Cognitive maps in hippocampus and orbitofrontal cortices were compressed so that locations cued as goals were coded together in neural state space, and these distortions predicted successful learning. This effect was captured by a computational model in which current and prospective locations are jointly encoded in a place code, providing a theory of how goals warp the neural representation of space in macroscopic neural signals. ### Competing Interest Statement The authors have declared no competing interest.

www.biorxiv.org

Tribute to Mark Stokes.
I was saddened to learn of the passing of my colleague Mark Stokes. Here is a video tribute I recorded for his festschrift in June 2022.
youtu.be/CpNLvFDMbhI

#neuroscience

R.I.P. Mark

Get Stoke(s)d!
Journal of Cognitive Neuroscience (2022) 35 (1): 1–3.
doi.org/10.1162/jocn_e_01938

Get Stoke(s)d! Introduction to the Special Focus

For the past 20 years, Mark Stokes has had a remarkably outsized influence on many areas of research within cognitive neuroscience. As an undergraduate at the University of Melbourne, in the laboratory of Jason Mattingley, he contributed to several studies pioneering the use of TMS for the study of human cognition (cf. Feredoes, 2023). Although many of these addressed fundamental questions about attention, arguably the most enduring of his contributions from that time was methodological, 2005's “Simple metric for scaling motor threshold based on scalp-cortex distance: Application to studies using transcranial magnetic stimulation” (Stokes et al., 2005). Google Scholar shows that although the citation count for this introduction of “the Stokes method” initially peaked in 2011, its year-by-year histogram has remained stubbornly elevated, achieving additional modes in 2017, in 2019, and now again in 2022 (for which, already by the 9-month mark, it has already eclipsed the previously most highly cited calendar year).For his PhD, Mark Stokes moved to Cambridge University where, in the laboratory of John Duncan, he was among the first to apply multivariate decoding analyses to neuroimaging studies of high-level cognition (cf. Duncan, 2023). Subsequently, he moved to Oxford University, initially to work with Kia Nobre as a research fellow and later establishing his own independent group and mentoring an impressive cohort of trainees (cf. Pike et al., 2023). Across his time at Oxford, he played a major role in bridging research on memory and attention, promoting a functional account of working memory in which forward-looking memory traces are informationally and computationally tuned for interacting with incoming sensory signals to guide adaptive behavior (Nobre & Stokes, 2019; cf. Myers, 2023; Nobre, 2023). In addition, and perhaps most influentially, soon after his arrival at Oxford, Mark Stokes turned his analytic acumen to developing a then-novel approach for the “retrospectively multivariate” analysis of data from single-unit extracellular recordings from awake, behaving animals. As recently as the decade of the 2000s, the preponderance of neurophysiological studies of nonhuman primates used the approach, during chronic recording sessions, of first isolating a single neuron, then recording from that neuron while the animal engaged in the behavior of interest, repeating this process across hundreds of recording sessions, then averaging the results across similarly tuned neurons. Stokes' insight was that one might learn more from such data sets by, rather than approaching them as a collection of univariate observations, treating them as a single multivariate observation by, in effect, pretending that these hundreds of units had all been recorded simultaneously. The results have been breathtakingly revealing.The first, and perhaps most impactful, of publications to come out of Mark Stokes' “retrospectively multivariate” enterprise was a product of his enduring collaborative relationship with John Duncan—a reanalysis of recordings from the pFC of nonhuman primates performing a working memory task (Sigala, Kusunoki, Nimmo-Smith, Gaffan, & Duncan, 2008). It reported the discovery that the population-level representation of stimulus information in pFC underwent a dynamic trajectory of state transitions that reflected task- and trial-specific context (Stokes et al., 2013; cf. Adam, Rademaker, & Serences, 2023). (For example, when a new stimulus appeared, its representation in pFC transitioned, over the course of just a few hundred milliseconds, from one primarily reflecting stimulus identity to one primarily reflecting whether it was a “target” [that would require a response] or a distractor [that would not].) Critically, because this information could be read out even during periods when the average firing rate in pFC did not differ from baseline, this finding implied that these dynamic transformations were occurring at the level of changing patterns of connectivity between neurons, rather than at the level of firing rates. It may well turn out that the most enduringly consequential impact to arise from this work will have been an insight that Stokes himself derived from it: There may be an “activity-silent” basis for the representation of information in working memory (Stokes, 2015). The wide-ranging implications of this proposal are being seen, seemingly every day, in new models and experimental results in disciplines ranging from experimental psychology to computational neuroscience to cellular neurobiology (cf. Buschman & Miller, 2023; Manohar, 2023).1Sadly for our field, personal circumstances have led to Dr. Stokes moving away from his role as Head of Attention group at Oxford's Department of Experimental Psychology. During the Summer of 2022, the contributions of this remarkable, and remarkably influential, cognitive neuroscientist were highlighted by an international gathering for a Stokes Fest[schrift] hosted on the grounds of New College (Figure 1). The articles collected in this Special Focus capture some of the spirit and ferment (cf. Wu & Buckley, 2023) that pervaded this celebration of the career of a dearly valued and admired colleague/mentor/teacher.Reprint requests should be sent to Bradley R. Postle, University of Wisconsin–Madison, 1202 West Johnson St., Madison, WI 53706, or via e-mail: bradpostle@gmail.com.National Institutes of Health (https://dx.doi.org/10.13039/100000002), grant number: MH095984.Retrospective analysis of the citations in every article published in this journal from 2010 to 2021 reveals a persistent pattern of gender imbalance: Although the proportions of authorship teams (categorized by estimated gender identification of first author/last author) publishing in the Journal of Cognitive Neuroscience (JoCN) during this period were M(an)/M = .407, W(oman)/M = .32, M/W = .115, and W/W = .159, the comparable proportions for the articles that these authorship teams cited were M/M = .549, W/M = .257, M/W = .109, and W/W = .085 (Postle and Fulvio, JoCN, 34:1, pp. 1–3). Consequently, JoCN encourages all authors to consider gender balance explicitly when selecting which articles to cite and gives them the opportunity to report their article's gender citation balance. The authors of this article report its proportions of citations by gender category to be as follows: M/M = .467; W/M = .267; M/W = 0; W/W = .267.

doi.org

RT @HelmholtzSchool
The program for the Helmholtz Lecture series 2022-2023 is finalized and updated! See helmholtzschool.nl/category/ag abstracts.

We are excited to announce that Cognitive Computational Neuroscience (CCN) 2023 will take place this year in Oxford from August 24 - 27, 2023! The conference will take place at the Examination Schools – more information can be found here:
venues.ox.ac.uk/our-venues/exa

My paper on the molecular memory code is now published!
sciencedirect.com/science/arti
Now the task is to work out the details and test the theory experimentally. Let me know if you want to help!

RT @swaziadam
Job position for assistant professor in psychology with a real-world focus that also includes climate.
@CameronBrick @ecotone2 @GreggRSparkman @MaibachEd @elkeweber @Sander_vdLinden @skepticscience

apol-recruit.ucsd.edu/JPF03496

I have a new paper out, yay! 

My paper, "Distinguishing guesses from fuzzy memories: Further evidence for item limits in visual working memory" with @kcs_adam, Joshua Foster and Edward Awh is published!

link.springer.com/article/10.3

#psychology #workingmemory #visualworkingmemory

"Even when the decisions themselves appeared bias free, women still bore extra time costs throughout the review process and were held to higher standards."

"female authors spent about 12 more days than comparable men revising their manuscripts. Women were also more likely to go through more rounds of review — three or more, compared with one or two for men."

#sexism #PeerReview

chronicle.com/article/are-wome

My book📚, “A Student’s Guide to Open Science: Using the Replication Crisis to Reform Psychology” is available to pre-order now! (tinyurl.com/59zk7m5y; tinyurl.com/2cukuy9v). A thread of why this book is important to both the field and me! 🧵

🍣We are hiring! 🍣 A postdoc or research scientist position in the Computational Group Dynamics Unit, RIKEN CBS, Tokyo (Wako). Expected starting in April 2023 (negotiable). Interested in social and collective human behaviour? See full details! 👉 cbs.riken.jp/en/careers/202212

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