Great to see the consequences of advanced paternal age given attention by The Guardian.
If anyone is attending #ASHG23 next week and wants to hear more, I'm giving a talk about this (and more).
"But problems pile up as a man gets older. Stem cells acquire more mutations. Epigenetic marks get modified. Experiences in the man’s life, including environmental exposures, cause oxidative stress and damage. These things, and more, may act in concert to cause the effects researchers are seeing in children born to older fathers.
What’s clear is that paternal age matters – and that more men are becoming older fathers. As Robaire and Chan write, a number of factors including delayed marriages, second marriages, assisted reproduction, treatments such as Viagra for erectile dysfunction, and celebrity men modelling older fatherhood “have provided elements for a perfect storm”."
