Sandra Laurentino @SandraLaurentino@qoto.org
#Reproductive biologist, group leader, PI in DFG CRU326 "Male Germ Cells", Geek.
Studying (in no particular order) #spermatogenesis, #gene regulation, #reproductive #ageing.
Associated editor for "Human Reproduction"
Living in lovely Münster 
All opinions are my own.
Joined Nov 2022
My colleague Joachim Wistuba is looking for a #PhDstudent for his fully funded
@dfg_public project on #KlinefelterSyndrome Deadline for application 27th December. More information on the position and how to apply here: https://jobs-sf.ukmuenster.de/job/UKM-Wissenschaftlicher-Mitarbeiter-%28gn%29/1011115001/
#PhDposition #Reproduction #Andrology
Sandra Laurentino
boosted
Congratulations to #Andronet member Hubert Schorle for his two recent publications:
Actl7b deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis https://doi.org/10.1242/dev.201593
Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human https://elifesciences.org/articles/86100
this last one having multiple Andronet members in the author list.
#Andrology #ReproductiveBiology #Reproduction
Sandra Laurentino
boosted
On becoming a cesspool
Such a stimulating session this morning on male infertility, I loved how many unexpected points of contact there were between the different speakers and what great company I was in. Thank you to Don Conrad and Maris Laan for the invitation to present my work on male reproductive ageing here.
#ASHG23
Really interesting selected talk by Christina Falugi about use of "natural" vs traditional photos of patients to showcase phenotypes. Perception is more positive with natural ones without difference in educational value. Time to retire some awful photos from textbooks?
#ASHG223
Random 1st impressions of the #ASHG2023:
It's not a large meeting, it's absolutely giganticConference ribbons are a thing Opening address included security advices for participantsClosed captions, I assume automatic/AI, are getting some words very, very wrong
Great to see the consequences of advanced paternal age given attention by The Guardian.
If anyone is attending #ASHG23 next week and wants to hear more, I'm giving a talk about this (and more).
"But problems pile up as a man gets older. Stem cells acquire more mutations. Epigenetic marks get modified. Experiences in the man’s life, including environmental exposures, cause oxidative stress and damage. These things, and more, may act in concert to cause the effects researchers are seeing in children born to older fathers.
What’s clear is that paternal age matters – and that more men are becoming older fathers. As Robaire and Chan write, a number of factors including delayed marriages, second marriages, assisted reproduction, treatments such as Viagra for erectile dysfunction, and celebrity men modelling older fatherhood “have provided elements for a perfect storm”."
Sandra Laurentino
boosted
Call to action on male infertility research
Several #Andronet members are co-authors of this Expert Recommendation on @NatRevUrol
"Frequency, morbidity and equity - the case for increased research on male fertility"
https://lnkd.in/eHQvVZ2s
Did you know that most men with #infertility don't receive a causal diagnosis? This is caused by a lack of knowledge around the factors responsible for male infertility. What is more, treatment options are limited and not individualised. Often, the burden of male infertility is simply transferred to the female partner during medically assisted reproduction. On the other hand, lack of rigorous research into male fertility also results in a relative lack of male contraceptives. In this article the authors identify the most pressing questions currently facing #andrology and make specific recommendations for action. Congratulations to the authors on this important piece of work 
3rd Virtual Symposium on Male Reproductive Immunology organised by the colleagues from Giessen will take place 29th-30th November. Great program and attendance is free!
The seminar series “Human Reproduction: Researching the Secrets of Life” will take place from Monday, 25 September until Thursday, 28 September 2023, every day 1:00 - 1:50 pm (CEST).
The seminar will be live-streamed via ZOOM (link to follow).
Sandra Laurentino
boosted
“So how long am I going to do this? Until indoor air is safe for all, until vaccines prevent transmission, until there’s a cure for long covid. Until I’m not risking my family’s future on a grocery run. The truth is that however immortal we feel, we are all just one infection away from a new life.”
Please read this key piece by Madeline Miller. The pandemic isn’t over until we can prevent Long COVID. https://www.washingtonpost.com/opinions/2023/08/09/madeline-miller-long-covid-post-pandemic/
Our new work was just published on BMC Bioinformatics
OGRE: calculate, visualize, and analyze overlap between genomic input regions and public annotations
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-023-05422-w
OGRE is a #bioinformatics tool that calculates the overlap between a set of genes or regions (e.g. coming from RNA-seq) and publically available #genomic annotations (e.g. TFBSs). It was developed to be easy to use and with scientists without computational training in mind.
It's available on @bioconductor https://bioconductor.org/packages/devel/bioc/html/OGRE.html and on
@GitHub https://github.com/svenbioinf/OGRE
Sandra Laurentino
boosted
The Andronet co-organised European Testis Workshop #ETW2023 is underway! Until Thursday there will be a lot of science and interaction between researchers studying testis.
Sandra Laurentino
boosted
On this day in 1902: Barbara McClintock born, won 1938 #NobelPrize for showing how chromosomes change #ThisDayInBiotech #WomenInBiotech
RT @MaleGermCells
Great opportunity for aspiring young scientists working in the field of reproductive research! Co-headed by #CRU326 speaker @JorgGromoll. Don‘t be shy and apply! https://twitter.com/repro_forschung/status/1654034136670117889
RT @Repro_Forschung
️Only six weeks to go️The deadline for applications for the @dfg_public Junior Research Academy #FertilAge is approaching fast!
Check out the program and the requirements on our websites and get your application ready! #ReproductiveHealth
https://reproduktionsforschung.de/dfg-nachwuchsakademie/
RT @matthewcobb
70 years ago, 3 papers appeared in @Nature under the title ‘Molecular structure of nucleic acids’. In an article in Nature today (link at end) @nccomfort and I shed new light on ‘what Watson and Crick really took from Rosalind Franklin’. This thread summarises our findings. 1/23
RT @pbeldade
A luso academia, com a devida vénia, claro está. https://twitter.com/JoaoM2215/status/1650400807928356865
#Reproductive biologist, group leader, PI in DFG CRU326 "Male Germ Cells", Geek.
Studying (in no particular order) #spermatogenesis, #gene regulation, #reproductive #ageing.
Associated editor for "Human Reproduction" Living in lovely Münster
All opinions are my own.
Joined Nov 2022
