ZEB_UniWue @ZEB_UniWue@qoto.org
Department of Cell & Developmental Biology in Würzburg. Research groups: Engstler, Janzen, Alsheimer, Kramer, Morriswood. Interested in #trypanosomes, #Tbrucei, #Leishmania, #MolecularParasitology, #CellBiology, #OneHealth, #NTDs, #Host_Pathogen_Interactions
#Parasitology paperwatch: short but potentially incredibly helpful paper from Michele Tinti & Mike Ferguson.
They reprocess their 2019 #Tbrucei #proteome turnover dataset to generate ranked protein abundances in BSFs & PCFs, & provide the results as a handy web app.
Now YOU too can readily access data on the relative abundance of individual proteins in those 2 life cycle stages!🤩👍👏
Only issue is that the link to the web app doesn't seem to be working any more😳 Anyone know what's happened?
#Parasitology paperwatch: recent review from Midori Ishii & Bungo Akiyoshi on #centromeres and #kinetochores. Principally describes the distinction between monocentric and holocentric centromeres, the role of the histone H3 variant CENP-A (when present) and their taxonomic distribution. It then touches on #kinetoplastid kinetochores and the riddle of what defines their centromeres at the end. 😀 👍 👏
https://www.sciencedirect.com/science/article/pii/S0955067422000011
#Parasitology paperwatch: justifiably bullish update on progress towards elimination of #HAT (#SleepingSickness) as a public health concern, & an outstanding example of the health benefits that can be achieved when national and international organisations can work together in a coordinated and sustained way to achieve a set goal.
Enriched by some useful charts of incidence and geographical distribution that are due to feature heavily in introductory slides for scientific talks over the next few years.
Despite the good news, the article maintains a sober and appropriately cautious tone throughout, noting caveats and remaining challenges while still previewing the next big target: elimination of #gHAT transmission
#Parasitology #preprint: new from Drew Etheridge lab (FA: N.Chasen
) looking at role of #myosins in #Tcruzi #endocytosis. Show MyoF+MyoC in complementary roles & also ID an essential new protein (MyAP) required for their targeting to the SPC🤩👍👏
#Parasitology paperwatch: recent work from
De Graffenried lab (FA: RS Muniz, PC Campbell) adapting a live-cell #imaging technique from bacteria to #trypanosomes, namely confinement of single cells to agarose microcells.
They show how the ability to track single cells over the entire cell cycle can lead to new insights. Show specifically that the 2 daughter cells produced after cell division go on to divide at different time (the one with the old flagellum is faster)
Also address recent controversy regarding a putative "backup cytokinesis" pathway triggered in TOEFAZ1/CIF1 RNAi, & show that the proposed pathway is not operating 🤩. Good description of how setup & imaging conditions were optimised & excellent suggestions for future applications of the approach😃👏👍
An #Introduction from us - we are the Department of #CellBiology & Developmental Biology at the University of #Würzburg in 🇩🇪. We love #trypanosomes! (and #trypanosomatids).
Toots will generally cover the following topics:
- News from the department (papers, PhDs, new arrivals).
- Papers of interest in #MolecularParasitology.
- Random observations about life in 🇩🇪 .
Great to be here and we're looking forward to connecting with the community! 
Department of Cell & Developmental Biology in Würzburg. Research groups: Engstler, Janzen, Alsheimer, Kramer, Morriswood. Interested in #trypanosomes, #Tbrucei, #Leishmania, #MolecularParasitology, #CellBiology, #OneHealth, #NTDs, #Host_Pathogen_Interactions
