Relative vs absolute fitness in a population genetics model. How stronger selection may promote genetic diversitySince the foundation of population genetics, it is believed that directional
selection should reduce genetic diversity. We present an exactly solvable
population model which contradicts this intuition. The population is modelled
as a cloud of particles evolving in a 1-dimensional fitness space (fitness
wave). We show the existence of a phase transition which separates the
parameter space into a weak and a strong selection regimes. We find that
genetic diversity is highly non-monotone in the selection strength and, in
contrast with the common intuition, our model predicts that genetic diversity
is typically higher in the strong selection regime. This apparent paradox is
resolved by observing that a higher selection strength increases the absolute
fitness of the wave, but typically generate lower relative fitness between
individuals within the wave. These findings entail that inferring the magnitude
of natural selection from genetic data may raise some serious conceptual
issues.
Along the way, we uncover a new phase transition in front propagation.
Namely, we show that the transition from weak to strong selection can be
reformulated in terms of a transition from fully-pulled to semi-pulled waves.
This transition is the pulled analog to the semi-pushed to fully-pushed regimes
observed in noisy-FKPP travelling waves in the presence of Allee effect.
arxiv.org