We consider the isentropic compressible Navier-Stokes-Poisson equations with degenerate viscousities and vacuum in a three-dimensional torus. The local well-posedness of classical solution is established by introducing a "quasi-symmetric hyperbolic"-"degenerate elliptic" coupled structure to control the behavior of the velocity of the fluid near the vacuum and give some uniform estimates. In particular, the initial data allows vacuum in an open set and we do not need any initial compatibility conditions.