We study the potentially undecidable problem of whether a given 2-dimensional CW complex can be embedded into $\mathbb{R}^4$. We provide operations that preserve embeddability, including joining and cloning of 2-cells, as well as $Δ\mathrm Y$-transformations. We also construct a CW complex for which $\mathrm YΔ$-transformations do not preserve embeddability. We use these results to study 4-flat graphs, i.e., graphs that embed in $\mathbb{R}^4$ after attaching any number of 2-cells to their cycles; a graph class that naturally generalizes planarity and linklessness. We verify several conjectures of van der Holst; in particular, we prove that each of the 78 graphs of the Heawood family is an excluded minor for the class of 4-flat graphs.