We establish the independence of multipliers for polynomial endomorphisms of $\mathbb C^n$ and endomorphisms of $\mathbb P^n.$ This allows us to extend results about the bifurcation measure and the critical height obtained in \cite{arXiv:2305.02246} to the case of polynomial endomorphisms of $\mathbb C^n$ for $n\geq 3$. An important step in the proof is the irreducibility of the spaces of endomorphisms with $N$ marked periodic points, which is of independent interest.