LapGM: A Multisequence MR Bias Correction and Normalization ModelA spatially regularized Gaussian mixture model, LapGM, is proposed for the
bias field correction and magnetic resonance normalization problem. The
proposed spatial regularizer gives practitioners fine-tuned control between
balancing bias field removal and preserving image contrast preservation for
multi-sequence, magnetic resonance images. The fitted Gaussian parameters of
LapGM serve as control values which can be used to normalize image intensities
across different patient scans. LapGM is compared to well-known debiasing
algorithm N4ITK in both the single and multi-sequence setting. As a
normalization procedure, LapGM is compared to known techniques such as: max
normalization, Z-score normalization, and a water-masked region-of-interest
normalization. Lastly a CUDA-accelerated Python package $\texttt{lapgm}$ is
provided from the authors for use.
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