We shall build a new science for a world that is not a machine.

A science built on true complexity, a wiser science that knows its limits.

A science more rigorous than the modern one, free of woo and mysticism.

expandingpossibilities.org/man

Text: @yoginho
Art: @mneustetter

Hey US-based Sciencers,

Do you use SGD (yeastgenome.org) they need a letter of support from you for a grant application. Check for an e-mail from Gavin Sherlock from earlier this month. I've asked for a link to share and will do so if I receive it. Otherwise, DM me for Gavin's contact info.

@Zamfr @futurebird came here to recommend this book! I had forgotten the exact analogies but I found them very interesting back in the day.

@futurebird

There is a nice attempt in Visual complex analysis, by Tristan Needham.
He first encourages you to see exp(x) as (1 + x/n)**n for n-> infinity. Interest paid out continuously, you know.

That has a nice geometric equivalent for complex exp(x + iy). Namely, a stack of n triangles with height y/n. As n goes to infinity, that stack is a spiral, or a circle if the real part is zero

Edit: and the circle then maps to cos and sin

Apropos of nothing, here is a legendary big band absolutely crushing it.

The Groove Merchant — Thad Jones/Mel Lewis Orchestra

youtu.be/4ZLvqXFddu0?t=23&si=O

Featuring Sir Roland Hanna at the top — not to be missed. Happy weekend!

@HumToTable @eosfpodcast

A large popular platform can be a safer, more diverse & more welcoming space.

I strongly dislike the tendency of people to abscond off into private communities. I don't like places that are not public & open. Mostly facebook groups convinced me that such places can be the most toxic places possible online.

I want a big public square and the intersections that such a place makes possible. I don't just want to talk to math people and tech people. I hate the isolation.

Irene Manton was a pioneer of electron microscopy.

She produced the first diagrammatic reconstruction of the 9+2 microtubular structure of the #cilium in 1952. When she showed her beautiful micrographs at international meetings, the audience would cheer and break into applause.

And she mortgaged her house to buy an electron microscope!

embrc.eu/newsroom/news/irene-m

#microscopy @biology #WomenInScience #science

Speaking as someone living in Hungary, to friends in the #USA:

The greatest weapon the system has is outrage fatigue. Doing so many unimaginable things at the same time that people just sigh and go on. Having so many things to protest that you run out of days and hours. Piling on so you start focusing on surviving with your bare mental health day to day.

Pick your cause and stick to it. Support others who focus on different causes. Don't try to do everything at once.

Hi! I'm a bot that shares research papers in EvoDevo (or Evolutionary Developmental Biology).

Currently, I index a few journals in the field and post links to articles that were published recently, one per day.

Since my posts are set to “quiet public”, they don't appear on Mastodon's feeds or hashtags searches. So, please, boost the papers you find worth sharing!

Any feedback is welcome. Thanks :)

#Introduction #EvoDevo #Papers #Research #DevBio #EvoBio

If women gave up every time we got evidence people hate us or just don't even consider us people, nothing would ever get done. So take a minute, feel/"honor" the awful feelings, because they're real, but then we're back to our regularly scheduled program of building the least-worst world we can.

Hi Mastodon! 👋

Dipping my toes here given the situation on the birdsite. I am Editor in Chief of #PLOSBiology, interested in all things science.

A virologist by training, I am passionate about #OpenScience and making publication process a transparent and constructive one.

I look forward to chatting about science, the evolving publishing landscape, traveling, cooking and a bit of everything!

From Weverthon Machado: “📊When teaching or giving a talk, do you like presenting plots step by step, revealing e.g. one group at a time? This is often useful for walking through complex results.

“I made a R package that makes it extremely easy to do this!

“ggreveal: Reveal a ggplot incrementally”

weverthon.com/ggreveal/

#rstats #dataviz #ggplot #ggplot2 @rstats #R

I remember seeing research pre-COVID on what kind of internal training engineering firms provided as a function of age and size: basically, histograms showing when firms start structuring learning, when they start hiring people to run training for staff, etc. Can't find it, web search is less useful than it used to be: if you have a link to a specific paper, I'd be grateful if you could post it here. thanks in advance

@multimeric Neat! I wonder what the “linguistic reasons” for avoiding J are?

Our new #preprint changes the way we look at an “extinction vortex” in which a small population loses fitness, causing it to become even smaller biorxiv.org/content/10.1101/20.
#MutationalMeltdown #EffectivePopulationSize #EvolutionaryRescue #PopulationGenetics #EvolGenPaper @wmawass @jdmatheson @uliseshmc 1/7

Extinction vortices are driven more by a shortage of beneficial mutations than by deleterious mutation accumulation

Natural populations are increasingly at risk of extinction due to climate change and habitat loss and fragmentation. The long-term viability of small populations can be threatened by an extinction vortex a positive feedback loop between declining fitness and declining population size. Two distinct mechanisms can drive an extinction vortex: i) ineffective selection in small populations allows deleterious mutations to fix, driving mutational meltdown, and ii) fewer individuals produce fewer of the novel beneficial mutations essential for long-term adaptation, a mechanism we term mutational drought. We measure the relative importance of each mechanism, on the basis of how sensitive beneficial vs. deleterious components of fitness flux are to changes in census population size near the critical population size at which fitness is stable. We derive analytical results given linkage equilibrium, complemented by simulations that capture the complex linkage disequilibria that emerge under high deleterious mutation rates. Even in the absence of environmental change, mutational drought can be nearly as important as mutational meltdown. Real populations must also adapt to a changing environment, making mutational drought more important. A partial exception is that mutational drought is somewhat less important when the beneficial mutation rate is high, although its contribution remains substantial. The critical population size is driven substantially higher by linkage disequilibria between deleterious and beneficial mutations, which also increase (albeit modestly) the importance of mutational drought.

bioRxiv

For night 28 of #31NightsOfHalloween #MicrosCreepy,
IT'S ALIVE! These are reanimated cell "ghosts," which are cells that have had their membranes/cytoplasm washed away, leaving the cytoskeleton behind. Adding ATP activates myosin motors, which causes contraction!

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