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"The human MPYS gene is highly heterogeneous (9, 10). Approximately 50% of Americans carry a non–wild-type (WT) (R232) MPYS allele (9). R71H-G230A-R293Q (HAQ) is the second most common human MPYS allele carried by ∼25% of Americans and ∼63% of East Asians (EAS) (9). Surprisingly, we recently found that HAQ knock-in mice do not respond to CDNs in vivo (11). In corroboration, Mogensen and colleagues (12) reported that homozygous HAQ MPYS/STING was enriched in HIV-infected individuals that were long-term nonprogressors."
