"To understand the basis for Ca2+ transport and signaling in Mtb, we determined Mtb’s transcriptional response to Ca2+. Overall, only few genes changed expression, suggesting a limited role of Ca2+ as a transcriptional regulator. However, 2 of the most strongly down-regulated genes were the pe15 and ppe20 genes that code for members of a large family of proteins that localize to the outer membrane and comprise many intrinsically disordered proteins."

#Tuberculosis #CalciumSignaling #PLOSBiology #Metabolism

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001906