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Model organism limitations
"Although many of the fundamental observations in murine models are expected to be similar in human tissue, it may still be difficult to directly transfer the observations to a human context. In particular, murine skin architecture is dominated by hair follicles, which are less frequent in human skin, leaving human skin with a larger proportion of much thicker interfollicular epidermis (22). Hence, to understand and translate the functions of the TGF-β signaling pathways into a human setting, it is important to use a human cellular and tissue system"
