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"Here, we analyze the consequences for CD8+ T cells of STAT3 GOF SH2 (K658N) or TA (T716M) domain mutations in the mouse germline and in people with germline STAT3 GOF syndrome. The findings demonstrate that diverse STAT3 GOF mutations cause oligoclonal accumulation of T-LGL-like effector CD8+ T cells and that the accumulation of these rogue T cells contributes to autoimmune pathology."
