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'In a now famous ‘eureka’ moment, in 1974, Franco Bottazzo, a research fellow in Deborah Doniach’s laboratory in London, was the first to successfully visualize islet cell antibodies using indirect immunofluorescence, thereby confirming the presence of antibodies reactive to the islet. During experiments originally designed to support his thesis work on Addison’s disease, he observed that pancreatic islets “lit up” after incubation with sera from some patients with polyendocrine autoimmunity, most of whom had or would go on to develop #diabetes.'
