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From a meeting report in #JournalImmunology:
"He (Jonathan Kagan) showed that old mice lose their naive CD8+ T cell repertoire, and the absence of CD8+ T cells in young mice reduces their survival rate. Protective immunity against cancer rises from CD4+ T cells in old mice, whereas CD8+ T cells are responsible for antitumor immunity in young mice."
@halama_immuno Absolutely - also highlights the need to keep an eye on CD4 cells when following the effects of things like checkpoint inhibitors, there is a bit a too much tunnel vision around CD8s in a lot of the ICI literature.
@cyrilpedia Tunnel Vision...very true!
@cyrilpedia indeed, tantalizing data...whether there is immunoageing or there is a shifting landscape in the recognized bugs/antigens/innate modulation...