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"Here, Sarden et al. aimed to characterize the mechanism by which resistance to Af fails in some individuals. The authors found that an axis consisting of innate B1a cells, natural IgG antibodies, and neutrophils is essential for maintaining protection against Af infection in preclinical models. This axis can be disrupted by factors ranging from influenza A and SARS-CoV-2 infection to corticosteroid treatment. Importantly, the authors showed that re-establishing this axis, including by administration of Af¬-reactive antibodies, can protect mice, highlighting a potential treatment"
