'Here, we performed uniform gain-of-function screens of all 44 human FOX transcription factors to identify and classify new regulators of the Wnt/β-catenin pathway. By combining β-catenin reporter assays with Wnt pathway-focused qPCR arrays and proximity proteomics of selected FOX family members, we determine that most FOX proteins are involved in the regulation of Wnt pathway activity and the expression of Wnt ligands and target genes.'

#Preprint #Wnt #TranscriptionFactor #MolecularBiology

https://www.biorxiv.org/content/10.1101/2022.12.13.520306v1?med=mas