'We identified three distinct types of ICI-myositis based on transcriptomic analyses. The IL6 pathway was overexpressed in all groups, the type I interferon pathway activation was specific for ICI-DM, the type 2 IFN pathway was overexpressed in both ICI-DM and ICI-MYO1, and only ICI-MYO1 patients developed myocarditis.'

#Preprint #immunotherapy #checkpointinhibitors

https://www.biorxiv.org/content/10.1101/2022.12.12.520136v1?med=mas