Follow
"Many proteins that can drive the formation of synaptic junctions share a similar property—they form strong bonds across the synapse and result in adhesive interactions. Using bacterial proteins not found in the mammalian nervous system, we engineered new adhesion molecules to test whether such adhesion is sufficient to drive the organization of synaptic junctions."
#Synapse #SynapseFormation #Neuroscience #MolecularNeuroscience
@cyrilpedia Interesting, and strange that the manuscript on inducing synapse formation with foreign adhesion molecules [1] doesn't mention GRASP (GFP reconstitution across synaptic partners) [2] which essentially does the same thing–strong bounds across membranes of two cells and which is suspected (or known?) to induce synapse formation or prevent their pruning.
[1] Hale et al. 2022 https://www.pnas.org/doi/10.1073/pnas.2215905120
[2] Feinberg et al. 2008 https://www.sciencedirect.com/science/article/pii/S0896627307010203
#neuroscience #GRASP