"However, despite deep knowledge about the genomic drivers of cancer—from oncogenic mutations to chromosomal rearrangements—we do not yet know how the spatial arrangement of the tumor microenvironment (TME) impacts pathogenesis; for instance, which feature types and spatial scales are relevant, how disease-associated histological features relate to molecular states, and whether morphological differences are discrete (like mutations) or continuous (like morphogen gradients)."

https://www.sciencedirect.com/science/article/pii/S0092867422015719