'To provide a comprehensive analysis of somatic mutations in the normal small intestine epithelium, we used the laser capture microdissection microscopy (LCM) and whole-genome sequenced 342 individual small intestine crypts from 39 individuals (173 duodenal from 22 individuals, 47 jejunal from 5 and 122 ileal from 16) aged between 4 and 82 years. Six had a history of celiac disease (gluten enteropathy).'