"A recent study showed that cells from individuals with Down syndrome had defects in forming primary cilia – structures on the surface of cells which work as signaling hubs to control how cells grow and develop. These cilia defects were in large part due to excess levels of a protein known as Pericentrin, which is encoded by a gene found on chromosome 21."

https://elifesciences.org/digests/78202/the-cell-biology-of-down-syndrome?utm_source=mastodon&utm_medium=social&utm_campaign=organic