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"Thus, studies of MSMD (Mendelian susceptibility to mycobacterial disease ) have revealed that human antimycobacterial immunity is a genetically controlled quantitative trait: the lower the level of IFN-γ activity, the more severe the disease and the higher its penetrance"
#immunology #InfetionImmunity #InfectiousDisease #mycobacterium #tuberculosis
@gpollara Comparing the IRF1 deficiency phenotype in this paper to the gamma interferon pathway mutants extensively described might generate some clues
@cyrilpedia
Yes, and that disconnect with IFNa/b responses also important to highlight.
The role of type I IFN in TB still to be worked out. They're there, but doing what?!
#infetionimmunity #infectiousdisease #mycobacterium #tuberculosis #immunology