"Current methodologies for tracking the behaviour of specific lymphocytes identify clones of a defined antigen-receptor - antigen binding affinity. However, lymphocytes can receive antigenic signals from undefined or endogenous antigens, and the strength of each signal, even for the same lymphocyte, varies with accessory signalling, across tissues and across time. We present a novel fate-mapping mouse, that, by tracking lymphocyte clones and their progenies from induced antigen signals, overcomes these hurdles and provides novel insights into the maintenance of tissue homeostasis."

#Preprint #immunology

https://www.biorxiv.org/content/10.1101/2023.03.16.532070v1?med=mas