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Models and their quirks:
"Here Muller was exceptionally lucky, because the somatic pairing of homologous chromosomes along their entire length—readily seen in #Drosophila—is not a general feature of eukaryotes."
@cyrilpedia @foaylward Excellent article. Embedded in it is the basic principles of (bio)information theory. “… the structure of the gene should make it possible to use all the information available…”, etc.
Muller was ahead of his time.
#informationtheory
A crucial topic often missing is gene control and expression.
@cyrilpedia
thx for the shoutout🙏 wasn't aware of this "link" but max delbrück probably was.
"But then… as he reaches the end of his analysis, Muller offers a stunning prediction. In essence he says that if you want to really understand the structure of the gene, it will not be done with Drosophila. Instead, he recommends the study of “d’Herelle bodies.” In 1917, the French physician Félix d’Hérelle discovered bacteriophage."
https://academic.oup.com/genetics/advance-article/doi/10.1093/genetics/iyad015/7058543?searchresult=1