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"Transcriptomic analysis of skate developing fins revealed a major reorganization of signalling gradients relative to other vertebrates1. The redeployment of developmental transcription factors, such as 3′ hox genes, initiates an anterior signalling centre analogous to the posterior apical ectodermal ridge (AER). These changes arose ~286–221 million years ago (Fig. 1b) after the divergence between sharks and skates. Nevertheless, the genomic and regulatory changes underlying these novel expression domains have remained elusive."
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